Another GLP-1 weight loss pill gets FDA approval, with fewer restrictions on how it’s used

I have bad IBS and had a similar experience over my 8 week trial (couldnt afford/justify more out of pocket). I hope the pills get covered because not having to plan everything around the nearest bathroom anymore would be nice. My friend just got diagnosed diabetic and is on it. He had it worse than me and no longer takes immodium every day, he doesnt have to use anything anymore. I miss having normal BMs

So rude of you to put your value of your body before value to the shareholders!

Your doctor can totally piss off your insurance into covering it. He/she can appeal a rejection for PA to consult with the insurance's doctor who made the decision to reject. From stories I've heard, there's a 50% chance they just approve it because they didn't have a doctor make the decision in the first place. I had a doctor fight for my PA, and he made it clear that he knew what he had to do because they all reject his prescription recommendations all the time so his office got very good at just pissing them off because they never could defend their rejection on follow up appeals. Now, this was still under patent (at the time) and they had drugs approved that had generic options, but we're talking like the OG medications that helped a little as opposed to medicine that treated the source of the problems. GLP-1 might be a different scenario.

My wife is **not** overweight, not obese, **but** her hormones and insulin blood results were all over the place and causing so many issues so her doctor put her on a monitor and they found she was having these wild blood insulin spikes many hours after eating and even while sleeping. These spikes would last a very long time and concerned her doctor. My wife works out a ton, eats at deficit and would just consistently maintain her weight even when by the standard CICO method she should be dropping some weight at a healthy rate. She was 135 and her ideal (feels healthiest at) weight was 115-120. So the doc put her on a glp-1 and guess what? Her random and prolonged insulin/blood sugar spikes stabilized and now she can lose weight with their workout/diet plan. So whenever I hear anyone suggesting GLP-1's are "cheating, hacking, for lazy fat people" I just ignore that shit. They can f*** off. I watched a woman struggle for 2 years busting her ass and feeling so defeated when she would watch me add and cut weight how and whenever I wanted throughout my fitness journey. I did everything to help her and she wasn't doing anything wrong with her planning/workouts. It just wasn't working. GLP-1's kicked her body physiology and biology in the ass and everything "works" again. Long story short, f*** the people that criticize this miracle drug.

I find the amount of "bUt yOU hAVE TO TAke tHE drUG evERYday foREVEr" moralizing to be wild. People do that already for any number of conditions that are less severe than every problem that comes with being overweight, and even any number of "healthy" people rely on daily caffeine. It's such a lack of perspective.

Because obesity is a morality issue to a lot of people and if they don't have anyone to call lazy and undisciplined, what else will they have?

It’s not negativity to point out it has risks. This is the first pharmaceutical that I feel like if you say anything bad about it people lose their minds. GLP-1s gave me gastroparesis. They can cause a host of other issues and long term use absolutely leads to muscle and bone density loss. They also absolutely won’t cure an ED and prescribing them to someone with an eating disorder seems insane. As with any weight loss drug, these are not a miracle cure and we shouldn’t ignore the risk of any medication just to lose a few pounds.

The horror stories I’ve always heard are from people who have stopped using it after meeting their goals etc. We need to hear more complete stories, not just the highs.

Imagine when more people are on it and demand for food drops, the food industry will spend so much to damn the medication.

From the studies, the family of drugs seems to [boost self control in general](https://sph.brown.edu/news/2025-07-24/brain-science-glp-1s-addiction). Eating is just the most obvious and visceral effect.

Yes! It gets rid of the food noise that fuels my eating disorder and makes my brain tell me that I need to restrict and lose weight. I’m able to eat in peace without my brain screaming at me to stop. It’s wonderful. ETA: best way to describe it is like how Vyvanse makes people with ADHD calm down, but normal people become hyper. The GLP-1s can help people with restrictive EDs maintain healthy weights. It’s counterintuitive, but it’s working for me!

It helps regulate appetite and makes you feel fuller for longer. This makes it easier to eat according to a plan rather than to be driven by cravings and perhaps compensating for that again by not eating.

Aren't those called vitamins?

Glp-1s do not work like stimulants at all. Stimulants suppress your appetite, you forget to eat. On semaglutide you get hungry like normal but are satiated sooner, because you digest slower. Not all that comparable.

I wish my Adderall helped me lose weight...

Hahahaha. Friend im on adderall and my mom put me on phentermine as a kid. Im 260 lbs. I have no appetite. Stimulants are not a miracle drug for complex weight issues. They are speed.

Improves it. Significantly. I started on Wegovy for chronic weight management a little over a year ago. Not only did the food noise go away immediately, but I stopped feeling cravings for nicotine. I haven’t been a full-time cigarette smoker for many years, but still enjoyed cigars or a pipe on a semi-regular basis. I stopped wanting it entirely. Same thing for alcohol; I was drinking a couple of pints of homebrew daily and have for several years. I rarely drink to get intoxicated, but along with food noise, I no longer felt a thirst for beer. On a hot day I’ll reach for a near beer, or when I’m out for dinner I’ll have a glass of wine, but the loaf of bread that I was drinking every day isn’t a problem any more. Wegovy flicked a switch. I’ve had to make a serious effort to go to the gym and make good dietary choices, but feel like I’m in control of my choices in a way that I’ve never been. I’ve never felt better in my entire adult life.

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Boy do we

Yeah the side effects are nothing to sneeze at. I can only tolerate the lowest dose and even then I still suffer a bit.

100%. I was on another widely touted medication and just kept passing out. I had to get off of it even though 98% of the population has no issues on it.

Thank you!!! Gastric side effects + potentially many other side effects. It’s great that this is working well for some people, but it’s still not a miracle cure for people that have other options.

Well, at least you can stop taking it. Can't get your intestines back

And it doesn't work for everyone...

Major gastric side effects!!! Gastroparesis is a super serious issue, along with crippling constipation. Also my friend on Wegovy just had an emergency gallbladder removal and her ER doc said they’ve been seeing quite a lot of this with GLP-1s. There is no magic pill. This comes with a whole host of side effects too.

Ask your doctor if Frostmourne is right for you.

Names like this are derived from a standardized process based on what the drug is and what it does. The name is aligned between the drug maker and organizations like the WHO. This is not the marketing name of the drug.

Also easier to travel with the pills. I flew with my pen and it was more stressful than expected trying to ensure the medicine stayed cold over the long flight.

I’ve recently looked into GLP1’s and the pill is interesting, but I’m not sure easier (save for being ‘not a needle’) since you have to take it separately from any other meds you’re on and inside a specific food window. The restrictions made it a non-starter for me.

I still don't get this drug. Do you lose weight because of the drug or because you don't eat anymore? Can you still eat 2 regular sized meals a day or does it make you not want to eat?

First identified in 1988, and very well studied.

Ok, that makes some sense. I appreciate the patient answer

I don't think the point is that the pill should work even when its no longer taken. The point is they still need to pursue long-term behavioral changes so they can eventually maintain it without the drug if possible. We still don't know the long-term effects so we shouldn't assume that decades of these drugs is a good standard of care for everyone. Maybe that should just be for more extreme cases. >it was some people being naturally built to get super fat and other people not being, and when the heavy people take the pill they get as skinny as people who don't have the gene. Everyone has a range of possible weights based on genetics and where they fall on that range depends on diet and exercise. Whether someone can sustain the diet and exercise needed to be on the healthier part of the range is complex and involves numerous factors like education, self-control/discipline, mental health, socioeconomics, etc. There is both a mental and physical component to it all so saying it was never willpower is not correct. It just wasn't only willpower. A fat person cannot simply blame genes as if they have no control.

I was under the understanding that big weight fluctuations are unhealthy. Is that incorrect?